Jellyfish have special cells along their tentacles called cnidocytes. Within these cells are harpoon-like structures full of venom, called nematocysts. The nematocysts shoot out when triggered by touch and can penetrate human skin in less time than it takes you to blink.
Once the venom is injected into your skin, the pain, redness and blistering begin. One of the main causes of this discomfort is a type of protein called a porin found in the venom of all jellyfish—and in all their relatives, including corals and anemones, which together form a group of creatures collectively known as cnidarians.